Kalzyme Studies

Kalzyme has been tested in clinical studies involving dogs and cats, as well as in laboratory settings. 

Kalzyme Dental Spray Studies

 Three studies involving a total of 79 dogs.

Study  Dogs Duration  Results

Placebo-controlled, double-blind, randomized study.
Unpublished study; data available from ZymIQ.

 45 28 days Gum health improved compared to placebo. Oral microbiome diversity increased. No adverse effects reported.

Controlled study at the Swedish University of Agricultural Sciences (SLU). Niklasson and Nylund, 2024.

 22 (12 received the spray, 10 did not) 26 days Gum health improved in the group receiving the spray. Tartar buildup increased in the group without the spray. The spray was described as easy to use.

Pilot study. Unpublished study; data available from ZymIQ.

 12 28 days Gum health improved. In dogs followed for a longer period, the effects were still observed more than 60 days after the start of the study.


What dog owners reported

85 % wanted to continue using the spray
Over 80 % were satisfied or very satisfied
7 in 10 noticed fresher breath
6 av 10 noticed cleaner teeth
Över 90 % found it easy to use.

No adverse effects reported

Before & After

In a case report, one dog received Kalzyme Dental Spray twice daily for four days. Plaque, visible in red after staining, decreased by approximately 29%.

Case report showing one dog on Day 1 and Day 4. Plaque stained red.

Learn More

  • The Science Behind

    Three studies on Dental Spray and dog owners' experiences.

  • Our Veterinarians

    Four veterinarians with over 100 years of combined experience.

  • About Kalzyme

    The Story Behind Kalzyme